Brain Changes During Menstruation

Brain Changes During Menstruation

Did you know that the average woman will experience about 450 menstrual cycles in her lifetime? Despite this, there has been a surprising lack of research into the hormonal effects of menstruation, particularly concerning its impact on the brain and mental health. However, a groundbreaking study has recently shed light on this elusive connection, revealing astonishing brainwide structural changes that correlate with hormonal fluctuations throughout the menstrual cycle.

Mental Health through the Menstrual Cycle

Neuroscientists have embarked on a fascinating journey, tracking 30 women through their menstrual cycles using a combination of MRI brain scans and hormone tests. The results have uncovered a complex interplay between hormones and the brain, challenging our previous understanding of the menstrual cycle’s influence on mental health.

Understanding the Brain-Hormone Cycle

During the study, researchers made several intriguing observations, providing valuable insights into the dynamic relationship between hormones and the brain. Notably:

1. Ovulation and Information Transfer

Just before ovulation, when estrogen levels peak, the researchers observed changes in the brain indicative of faster information transfer. This suggests that hormonal fluctuations are not confined to reproductive organs but extend their influence to cognitive processes.

2. FSH and Gray Matter Thickness

The rise of Follicle-Stimulating Hormone (FSH) before ovulation was associated with thicker gray matter in the brain. This finding raises questions about the role of FSH in neurological processes and adds a new layer to our understanding of hormonal effects on brain structure.

3. Progesterone and Cerebrospinal Fluid Volume

After ovulation, higher levels of progesterone were correlated with decreased cerebrospinal fluid volume. This discovery challenges conventional notions about the isolated impact of hormones on reproductive organs, emphasizing the far-reaching effects of hormonal changes throughout the menstrual cycle.

Hormonal Brain Changes

Hormones & Mental Health: What We Know

The implications of this study extend beyond the reproductive system. The intricate connections between hormones and the brain suggest a domino effect that reaches far beyond the ovaries and uterus. Understanding these hormone-brain connections is crucial for comprehending the broader impact on female hormone balance and mental health.

New Study

While the study is not yet peer-reviewed, its findings are groundbreaking and have the potential to reshape our understanding of the female brain and its intricate relationship with hormonal fluctuations. The study is currently available as a preprint, inviting further exploration and discussion within the scientific community.

New Frontier in Women’s Health Research

The revelations from this study challenge preconceived notions and invite us to reconsider the scope of hormonal influence on the female brain. The intricate dance between hormones and brain structure opens up a new frontier in women’s health research, providing a glimpse into the complexity of the menstrual cycle’s impact on mental well-being.

As we delve deeper into the connections between hormones and the brain, we unlock a treasure trove of insights into the female experience. This study marks a significant step forward in understanding the nuanced interplay between hormonal fluctuations and mental health throughout the menstrual cycle. Stay tuned for further developments in this exciting field of research.


Rizor EJ, Babenko V, Dundon NM, et al. “Menstrual cycle-driven hormone concentrations co-fluctuate with white and grey matter architecture changes across the whole brain.” bioRxiv, 2023. [link]

Share this post

Ready for a Reset?

Register for the WILDFIT 14 Day Reset.  Space is limited, Join Now!

Ready to move beyond temporary fixes for your health concerns? Say goodbye to guesswork and uncover the root causes of your health issues with a free consultation.